Case report<br>Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Ewa Iżycka-Świeszewska; Wojciech Wesołowski; Blanka Hermann

doi:10.5114/pjp.2015.53016

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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2/2015
vol. 66

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abstract:

Case report
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Ewa Iżycka-Świeszewska

,

Wojciech Wesołowski

,

Blanka Hermann

Pol J Pathol 2015; 66 (2): 195-199

DOI: https://doi.org/10.5114/pjp.2015.53016

Online publish date: 2015/07/28

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Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases – a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.

keywords:

Case reportExtracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Ewa Iżycka-Świeszewska , Wojciech Wesołowski , Blanka Hermann

rhabdomyoma, cellular signaling, AKT/mTOR, extracardiac

Case report
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling

Ewa Iżycka-Świeszewska

,

Wojciech Wesołowski

,

Blanka Hermann