Advances in Dermatology and Allergology
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eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
6/2012
vol. 29
 
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abstract:

Review paper
Vitamin C: is it time to re-evaluate its role in health and disease?

Ryszard Rutkowski
,
Krzysztof Rutkowski
,
Joanna Rutkowska-Talipska
,
Paweł Sowa
,
Stanisław Sulkowski

Postep Derm Alergol 2012; XXIX, 6: 456-460
DOI: https://doi.org/10.5114/pdia.2012.32394
Online publish date: 2012/12/21
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Vitamin C (VC; ascorbic acid, AA) is synthesised from glucose in the liver of most mammals, but not in humans. Synthetic AA supplementation is often necessary to prevent vitamin C deficiency. Intracellularly AA is reversibly oxidized to an ascorbic radical which converts into dehydroascorbic acid (DHA). Ascorbic acid crosses cell membranes with SVCT1, SVCT2 or GLUT1, GLUT3 and GLUT4 transporters. Recommended daily allowance for VC is around 75 mg/day for women and 90 mg/day for men. This seems to be too low in relation to real human body needs and does not ensure true health protection. There are ongoing studies re-evaluating the role of VC in cancer treatment. Therefore, it would be also appropriate to reassess its use as a specific drug in the prevention and therapy of asthma, allergic rhinitis and atopic dermatitis.
keywords:

vitamin C, deficiency, absorption, recommended dietary allowance, therapy

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