Advances in Dermatology and Allergology
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eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2012
vol. 29
 
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abstract:

Review paper
Status of combination drugs with betamethasone dipropionate and salicylic acid in the treatment of skin diseases

Marta Pastuszka
,
Andrzej Kaszuba

Postep Derm Alergol 2012; XXIX, 3: 196–204
[Polish version: Postep Derm Alergol 2012; XXIX, 3: 205–214]
Online publish date: 2012/07/27
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Combinations of topical glucocorticoids (GCs) with other substances are very often used in dermatology. One of the most common combinations is betamethasone dipropionate and salicylic acid. Betamethasone dipropionate is a potent topical glucocorticoid (belonging to class III according to the European classification) which demonstrates anti-inflammatory, anti-proliferative, immunosuppressive and vasoconstrictive properties. Salicylic acid, in turn, has a strong keratolytic and slightly antiseptic action. The use of both components in one formulation provides a significantly better GC penetration through the skin, which is crucial for the treatment of hyperkeratotic lesions.
keywords:

betamethasone dipropionate, salicylic acid, mechanism of action, therapy

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