The <i>EVER </i>genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients

Agnieszka Kalińska-Bienias; Cezary Kowalewski; Sławomir Majewski

doi:10.5114/ada.2016.59145

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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2/2016
vol. 33

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abstract:

Review paper

**The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients**

Agnieszka Kalińska-Bienias

,

Cezary Kowalewski

,

Sławomir Majewski

Adv Dermatol Allergol 2016; XXXIII (2): 75–80

DOI: https://doi.org/10.5114/ada.2016.59145

Online publish date: 2016/05/16

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AMA

Kalińska-Bienias A, Kowalewski C, Majewski S. The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(2):75-80. doi:10.5114/ada.2016.59145.

APA

Kalińska-Bienias, A., Kowalewski, C.,  & Majewski, S. (2016). The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(2), 75-80. https://doi.org/10.5114/ada.2016.59145

Chicago

Kalińska-Bienias, Agnieszka, Cezary Kowalewski,  and Sławomir Majewski. 2016. "The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (2): 75-80. doi:10.5114/ada.2016.59145.

Harvard

Kalińska-Bienias, A., Kowalewski, C.,  and Majewski, S. (2016). The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(2), pp.75-80. https://doi.org/10.5114/ada.2016.59145

MLA

Kalińska-Bienias, Agnieszka et al. "The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 2, 2016, pp. 75-80. doi:10.5114/ada.2016.59145.

Vancouver

Kalińska-Bienias A, Kowalewski C, Majewski S. The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(2):75-80. doi:10.5114/ada.2016.59145.

In recent years, the two adjacent novel EVER1 and EVER2 genes have been identified, whose mutations are responsible for the development of epidermodysplasia verruciformis (EV). Epidermodysplasia verruciformis is a rare, autosomal recessive genodermatosis associated with increased risk of skin carcinoma. Up to now 7 mutations in the EVER1 gene and 5 mutations in the EVER2 gene have been identified only in EV. It was also determined that the EVER genes belong to a novel gene family, the transmembrane channel-like (TMC) family, and are responsible for properly functioning zinc homeostasis. These observations have given new insights into EV pathogenesis.

keywords:

The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients

Agnieszka Kalińska-Bienias , Cezary Kowalewski , Sławomir Majewski

epidermodysplasia verruciformis, EVER genes and proteins, carcinogenesis

**The EVER genes – the genetic etiology of carcinogenesis in epidermodysplasia verruciformis and a possible role in non-epidermodysplasia verruciformis patients**

Agnieszka Kalińska-Bienias

,

Cezary Kowalewski

,

Sławomir Majewski