Studia Medyczne

The use of transferrin isoforms to differentiate cholestatic liver diseases

Lech Chrostek 1
,
Alicja Bauer 2
,
Ewa Gruszewska 1
,
Bogdan Cylwik 3

  1. Department of Biochemical Diagnostics, Medical University of Bialystok, Poland

  2. Department of Biochemistry and Molecular Biology, Centre of Postgraduate Medical Education, Warsaw, Poland

  3. Department of Paediatric Laboratory Diagnostics, Medical University of Bialystok, Poland

Medical Studies

DOI: https://doi.org/10.5114/ms.2026.162171
Data publikacji online: 2026/06/05
Article file
The use of transferrin.pdf
Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
  1. Sarcognato S, Sacchi D, Grillo F, Cazzagon N, Fabris L, Cadamuro M, Cataldo I, Covelli C, Mangia A, Guido M. Autoimmune biliary diseases: primary biliary cholangitis and primary sclerosing cholangitis. Pathologica. 2021; 113: 170-184.
  2. Vlădut C, Ciocîrlan M, Bilous D, Sandru V, Stan-Ilie M, Panic N, Becheanu G, Jinga M, Costache RS, Costache DO, Diculescu M. An overview on primary sclerosing cholangitis. J Clin Med. 2020; 9: 754.
  3. https://www.icd10data.com/ICD10CM/Codes
  4. Lindor KD, Kowdley KV, Harrison ME. ACG clinical guideline: primary sclerosing cholangitis. Am J Gastroenterol. 2015; 110: 646-659.
  5. European Association for the Study of the Liver. EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis. J Hepatol. 2017; 67: 145-172.
  6. Hirschfield GM, Dyson JK, Jones DEJ, Alexander GJM, Chapman MH, Collier J, Hübscher S, Patanwala I, Pereira SP, Thain C, Thorburn D, Tiniakos D, Walmsley M, Web- ster G, Jones DEJ. The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut. 2018; 67: 1568-1594.
  7. de Vries E, Wang J, Leeflang M, Boonstra K, Weersma R, Beuers U, Geskus RB, Ponsioen CY. Alkaline phosphatase at diagnosis of primary sclerosing cholangitis and 1 year later: evaluation of prognostic value. Liver Int. 2016; 36: 1867-1875.
  8. Chapman MH, Thorburn D, Hirschfield GM, Webster G, Rushbrook SM, Alexander G, Collier J, Dyson JK, Jo- nes DE, Patanwala I, Thain C, Walmsley M, Pereiraet SP. British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis. Gut. 2019; 68: 1356-1378.
  9. Grytczuk A, Bauer A, Gruszewska E, Cylwik B, Chrostek L. Changed profile of serum transferrin isoforms in primary biliary cholangitis. J Clin Med. 2020; 9: 2894.
  10. Gruszewska E, Wrona A, Gudowska M, Panasiuk A, Cylwik B, Lipartowska-Klimuk K, Flisiak R, Chrostek L. The transferrin isoforms in chronic hepatitis. Clin Biochem. 2017; 50: 1131-1135.
  11. Gudowska M, Gruszewska E, Panasiuk A, Cylwik B, Swiderska M, Flisiak R, Szmitkowski M, Chrostek L. Changed profile of serum transferrin isoforms in liver diseases. Clin Lab. 2017; 63: 349-354.
  12. Bauer A, Habior A. detection of autoantibodies against nucleoporin p62 in sera of patients with primary biliary cholangitis. Ann Lab Med. 2019; 39: 291-298.
  13. Trivedi PJ, Hirschfield GM. Treatment of autoimmune liver disease: current and future therapeutic options. Ther Adv Chronic Dis. 2013; 4: 119-141.
  14. Floreani A, Mangini C. Primary biliary cholangitis: old and novel therapy. Eur J Intern Med. 2018; 47: 1-5.
  15. Iravani S, Dooghaie-Moghadam A, Razavi-Khorasani N, Moazzami B, Beirami AD, Mansour-Ghanaei A, Majidzadeh-A K, Mehrvar A, Khoshdel A, Toosi MN, Sadeghi A. An update on treatment options for primary sclerosing cholangitis. Gastroenterol Hepatol Bed Bench. 2020; 13: 115-124.
  16. Gao L, Wang L, Woo E, He XS, Yang GX, Bowlus C, Leung PSC, Gershwin ME. Clinical management of primary biliary cholangitis – strategies and evolving trends. Clin Rev Allergy Immunol. 2020; 59: 175-194.
  17. Trivedi PJ, Muir AJ, Levy C, Bowlus CL, Manns MP, Lu X, Crans G, Chung C, Subramanian GM, Myers RP, Goodman Z, Chalasani N, Vierling JM, Guha IN, Hirschfield GM. Intra-individual variation, and limited prognostic utility of serum alkaline phosphatase in a trial of patients with primary sclerosing cholangitis. Clin Gastroenterol Hepatol. 2021; 19: 1248-1257.
  18. Kamboh MI, Ferrell RE. Human transferrin polymorphism. Hum Hered. 1987; 37: 65-81.
  19. De Jong G, Van Dijk JP, Van Eijk HG. The biology of transferrin. Clin Chim Acta. 1990; 190: 1-46.
  20. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999; 340: 448-454.
  21. Gruszewska E, Cylwik B, Matus L, Gudowska M, Szmitkowski M, Kedra B, Chrostek L. Changes in transferrin isoforms in pancreatic cancer. Ann Clin Lab Sci. 2016; 46: 286-290.
  22. Cylwik B, Gruszewska E, Gindzienska-Sieskiewicz E, Kowal-Bielecka O, Chrostek L. Serum profile of transferrin isoforms in rheumatoid arthritis treated with biological drugs. Clin Biochem. 2019; 74: 31-35.
Copyright: © 2026 Jan Kochanowski University in Kielce This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
SUBMIT YOUR PAPER
Share
without publication fees
Coverage in
Integrated with
plagiat pl
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications